The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity

The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for >15 000 traits, from which more than 625 000 lead associations have been curated. Additionally, 85 000 full genome-wide summary statistics datasets-containing association data for all variants in the analysis-are available for downstream analyses such as meta-analysis, fine-mapping, Mendelian randomisation or development of polygenic risk scores. As a centralised repository for GWAS results, the GWAS Catalog sets and implements standards for data submission and harmonisation, and encourages the…

• EM
  European Molecular Biology Laboratory
• BH
  British Heart Foundation
• DO
  Department of Health and Social Care
• PH
  Public Health Agency
• NI
  National Institutes of Health
• CS
  Chief Scientist Office, Scottish Government Health and Social Care Directorate
• MR
  Medical Research Council

  Award: HDR-23007
• EA
  Engineering and Physical Sciences Research Council
• EA
  Economic and Social Research Council
• HA
  Health and Social Care Research and Development Division
• NC
  NIHR Cambridge Biomedical Research Centre

  Award: NIHR203312
• NH
  National Human Genome Research Institute

  Awards: RM1 HG010860, 1U24HG012542-01
• NO
  NIH Office of the Director

  Award: R24 OD011883
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: UM1DK105554
• HD
  Health Data Research UK