CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases

Background Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer peritoneal metastasis (GCPM) have a poor prognosis and respond poorly to conventional treatments. Recently, immune checkpoint blockade (ICB) has demonstrated favourable efficacy in the treatment of GCPM. Stratification of best responders and elucidation of resistance mechanisms of ICB therapies are highly important and remain major clinical challenges. Design We performed a phase II trial involving patients with GCPM treated with ICB (sintilimab) combined with chemotherapy. The samples of primary tumours, GCPMs and peripheral blood from patients were collected for single-cell sequencing to…

• NN
  National Natural Science Foundation of China

  Awards: 82321003, 32370698, 92374114, 82173128, 82273402, 81930065, 82103586
• NS
  Natural Science Foundation of Guangdong Province

  Awards: 2014A030312015, 2024A1515012888, 2019A1515011109
• NK
  National Key Research and Development Program of China

  Award: 2021YFA1302100
• SA
  Science and Technology Planning Project of Guangdong Province

  Award: 2019B020227002
• GS
  Guangdong Special Support Plan

  Award: 2023TX07Y430
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2022A1515012458, 2023B1515040030