articleNucleic Acids ResearchNov 18, 2024GOLD OA

The STRING database in 2025: protein networks with directionality of regulation

DSDamian SzklarczykKNKaterina NastouMKMikaela KoutrouliRKRebecca KirschFMFarrokh Mehryary

SIB Swiss Institute of Bioinformatics · University of Zurich · +6 more institutions

PubMed
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Abstract

Proteins cooperate, regulate and bind each other to achieve their functions. Understanding the complex network of their interactions is essential for a systems-level description of cellular processes. The STRING database compiles, scores and integrates protein-protein association information drawn from experimental assays, computational predictions and prior knowledge. Its goal is to create comprehensive and objective global networks that encompass both physical and functional interactions. Additionally, STRING provides supplementary tools such as network clustering and pathway enrichment analysis. The latest version, STRING 12.5, introduces a new 'regulatory network', for which it gathers evidence on the type…

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Topics & keywords

Topics
Keywords
  • Biology
  • Directionality
  • String (physics)
  • Computational biology
  • Evolutionary biology
  • Genetics
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