InterPro: the protein sequence classification resource in 2025

InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to classify sequences into families and predict the presence of domains and significant sites. The InterPro database provides annotations for over 200 million sequences, ensuring extensive coverage of UniProtKB, the standard repository of protein sequences, and includes mappings to several other major resources, such as Gene Ontology (GO), Protein Data Bank in Europe (PDBe) and the AlphaFold Protein Structure Database. In this publication, we report on the status of InterPro (version 101.0),…

• WT
  Wellcome Trust

  Award: 221 320/Z/20/Z
• EM
  European Molecular Biology Laboratory
• UR
  UK Research and Innovation
• EC
  European Commission
• NI
  National Institutes of Health
• DF
  Directorate for Biological Sciences
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/X018660/1, BB/S020381/1, BB/X012492/1, BB/X012492/1, BB/S020381/1, BB/X018563/1, BB/X018660/1
• UN
  U.S. National Library of Medicine
• CN
  Centro Nacional de Biotecnología