Mineralized collagen plywood contributes to bone autograft performance

Autologous bone (AB) is the gold standard for bone-replacement surgeries1, despite its limited availability and the need for an extra surgical site. Traditionally, competitive biomaterials for bone repair have focused on mimicking the mineral aspect of bone, as evidenced by the widespread clinical use of bioactive ceramics2. However, AB also exhibits hierarchical organic structures that might substantially affect bone regeneration. Here, using a range of cell-free biomimetic-collagen-based materials in murine and ovine bone-defect models, we demonstrate that a hierarchical hybrid microstructure—specifically, the twisted plywood pattern of collagen and its association with poorly crystallized…

• ES
  European Synchrotron Radiation Facility
• IN
  Institut National de la Santé et de la Recherche Médicale
• CN
  Centre National de la Recherche Scientifique
• FD
  Fondation du Collège de France
• FE
  Fondation EDF
• SD
  Société d'Accélération du Transfert de Technologies
• UD
  Université de Paris