Atlas of the plasma proteome in health and disease in 53,026 adults

Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing the most comprehensive proteome profiles to date. This atlas revealed 168,100 protein-disease associations and 554,488 protein-trait associations. Over 650 proteins were shared among at least 50 diseases, and over 1,000 showed sex and age heterogeneity. Furthermore, proteins demonstrated promising potential in disease discrimination (area under the curve [AUC] > 0.80 in 183…

• NN
  National Natural Science Foundation of China

  Awards: 82071201, 82471940, 82472055, STI2030, 82271471, 82071997, 2022ZD0211600, 92249305, 2018SHZDZX01
• FU
  Fudan University

  Awards: 3030277001, 2018SHZDZX01
• HH
  Huashan Hospital

  Award: 2022QD002
• HE
  Higher Education Discipline Innovation Project

  Award: B18015
• NP
  National Postdoctoral Program for Innovative Talents

  Award: BX20230087
• NK
  National Key Research and Development Program of China

  Awards: STI2030, 2018SHZDZX01, 2023YFC3605400
• PO
  Program of Shanghai Academic Research Leader

  Award: 23XD1420400
• NI
  National Institute on Aging