miRTarBase 2025: updates to the collection of experimentally validated microRNA–target interactions
Chinese University of Hong Kong, Shenzhen · Chinese Academy of Medical Sciences & Peking Union Medical College · +3 more institutions
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs (18-26 nucleotides) that regulate gene expression by interacting with target mRNAs, affecting various physiological and pathological processes. miRTarBase, a database of experimentally validated miRNA-target interactions (MTIs), now features over 3 817 550 validated MTIs from 13 690 articles, significantly expanding its previous version. The updated database includes miRNA interactions with therapeutic agents, revealing roles in drug resistance and therapeutic strategies. It also highlights miRNAs as predictive, safety and monitoring biomarkers for toxicity assessment, clinical treatment guidance and therapeutic optimization. The expansion of miRNA-mRNA and…
Citation impact
- FWCI
- 45.73
- Percentile
- 100%
- References
- 81
Authors
17- SCShidong Cui
Chinese University of Hong Kong, Shenzhen
- SYSicong Yu
Chinese University of Hong Kong, Shenzhen
- HHHsi-Yuan Huang
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Chinese University of Hong Kong, Shenzhen
- YLYang-Chi-Dung Lin
Chinese University of Hong Kong, Shenzhen
- YHYixian Huang
Chinese University of Hong Kong, Shenzhen
Topics & keywords
- Biology
- microRNA
- Computational biology
- Genetics
- Gene