Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
First Affiliated Hospital of Guangzhou Medical University · State Key Laboratory of Respiratory Disease · +3 more institutions
Abstract
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest that lipid peroxidation can be the common feature that initiates and propagates the cell death. Excessive lipid peroxidation alters the property of membrane and further damage the proteins and nucleic acids, which is implicated in various human pathologies. Here, we firstly review the classical chain process of lipid peroxidation, and further clarify the current understanding of the myriad roles and molecular mechanisms of lipid peroxidation in various RCD types. We also…
Citation impact
- FWCI
- 44.90
- Percentile
- 100%
- References
- 279
Authors
5- YZYongxin Zheng
First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
- JSJunlu Sun
First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
- ZLZhiting Luo
First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
- YLYimin Li
Guangzhou Experimental Station, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Dermatology, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
- YHYongbo HuangCorresponding
First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
Topics & keywords
- Lipid peroxidation
- Programmed cell death
- Cell biology
- Apoptosis
- Biology
- Oxidative stress
- Chemistry
- Biochemistry
- Good health and well-being