Epigenetics-targeted drugs: current paradigms and future challenges

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzymes convey genetic information independently of DNA base sequences, playing essential roles in organismal development and homeostasis. Conversely, disruptions in epigenetic landscapes critically influence the pathogenesis of various human diseases. This understanding has laid a robust theoretical groundwork for developing drugs that target epigenetics-modifying enzymes in pathological conditions. Over the past two decades, a growing array of small molecule drugs targeting…

• CP
  China Postdoctoral Science Foundation

  Award: 2023M733902
• DO
  Department of Science and Technology of Sichuan Province

  Awards: 82071651, 23ZDYF2489
• SU
  Sichuan University
• CM
  China Medical University
• CS
  Chengdu Science and Technology Bureau

  Award: 2017-GH02-00030-HZ
• NK
  National Key Research and Development Program of China

  Awards: 2022YFC3600304, 2022YFC2704700
• SH
  Shengjing Hospital