Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia
University College London Hospitals NHS Foundation Trust · University Hospitals Bristol NHS Foundation Trust · +2 more institutions
Abstract
Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persistence.
We conducted a phase 1b-2 multicenter study of obe-cel in adults (≥18 years of age) with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). The main cohort, cohort 2A, included patients with morphologic disease; patients in cohort 2B had measurable residual disease. The primary end point was overall remission (complete remission or complete remission with incomplete hematologic recovery) in cohort 2A. Secondary end points included event-free survival, overall survival, and safety.
Citation impact
- FWCI
- 46.46
- Percentile
- 100%
- References
- 10
Authors
31- CRClaire RoddieCorresponding
University College London Hospitals NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, University College London
- KSKaramjeet Sandhu
University College London Hospitals NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, University College London
- ETEleni Tholouli
University College London Hospitals NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, University College London
- ACAaron C. Logan
University College London Hospitals NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, University College London
- PSPaul Shaughnessy
University College London Hospitals NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, University College London
Topics & keywords
- Lymphoblastic Leukemia
- Cancer research
- Medicine
- Leukemia
- Internal medicine