Neutrophil diversity and function in health and disease

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells, thereby initiating downstream signal transduction pathways. Dysfunctions in neutrophils and disruptions in neutrophil…

• NS
  Natural Science Foundation of Jilin Province

  Award: Grant No.20210101310JC
• JP
  Jilin Province Development and Reform Commission

  Award: 2023C028-6
• PG
  People's Government of Jilin Province
• JU
  Jilin University
• JS
  Jilin Scientific and Technological Development Program

  Awards: 20210101010JC, 20210203080SF, 20220505033ZP
• FH
  First Hospital of Jilin University