Overcoming Challenges in Small-Molecule Drug Bioavailability: A Review of Key Factors and Approaches
University of California, Los Angeles · Charles R. Drew University of Medicine and Science · +3 more institutions
Abstract
The bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical development, significantly impacting therapeutic efficacy and commercial viability. This review synthesizes recent advances in understanding and overcoming bioavailability limitations, focusing on key physicochemical and biological factors influencing drug absorption and distribution. We examine cutting-edge strategies for enhancing bioavailability, including innovative formulation approaches, rational structural modifications, and the application of artificial intelligence in drug design. The integration of nanotechnology, 3D printing, and stimuli-responsive delivery systems are highlighted as promising avenues for…
Citation impact
- FWCI
- 46.81
- Percentile
- 100%
- References
- 184
Authors
7- KWKe Wu
University of California, Los Angeles, Charles R. Drew University of Medicine and Science
- SHSoon Hwan Kwon
University of California, Los Angeles, Charles R. Drew University of Medicine and Science
- XZXuhan Zhou
University of California, Santa Barbara
- CFClaire Fuller
Johns Hopkins University
- XWXianyi Wang
University of Illinois Urbana-Champaign
Topics & keywords
- Bioavailability
- Drug delivery
- Biochemical engineering
- Personalization
- Nanotechnology
- Computer science
- Risk analysis (engineering)
- Pharmacology
Funding
- NINational Institutes of HealthAwards: SC1CA200517, U54MD007598, GM135050-05, NIH/NCI1U54CA14393, U56 CA101599-01, UL1TR000124
- NCNational Cancer InstituteAwards: SC1CA200517, U54MD007598, UL1TR000124
- NCNational Center for Advancing Translational SciencesAward: UL1TR000124
- NINational Institute on Minority Health and Health DisparitiesAwards: G0812D05, SC1CA200517, UL1TR000124, U54MD007598, CA101599-01, BC043180