articleNucleic Acids ResearchDec 9, 2024GOLD OA

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

MMMitja M. ZdoucKBKai BlinNLNico L L LouwenJCJorge C. Navarro-MuñozCLCatarina Loureiro

Wageningen University & Research · Novo Nordisk Foundation · +160 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version…

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Topics & keywords

Topics
Keywords
  • Biology
  • Gene cluster
  • Data curation
  • Cluster (spacecraft)
  • Computational biology
  • Gene
  • Genetics
  • Data science
UN Sustainable Development Goals
  • Zero hunger
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