Ferroptosis: when metabolism meets cell death

We present here a comprehensive update on recent advancements in the field of ferroptosis, with a particular emphasis on its metabolic underpinnings and physiological impacts. After briefly introducing landmark studies that have helped to shape the concept of ferroptosis as a distinct form of cell death, we critically evaluate the key metabolic determinants involved in its regulation. These include the metabolism of essential trace elements such as selenium and iron; amino acids such as cyst(e)ine, methionine, glutamine/glutamate, and tryptophan; and carbohydrates, covering glycolysis, the citric acid cycle, the electron transport chain, and the pentose phosphate pathway. We also delve into the mevalonate…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: #461507177, #461385412, CO 291/11-1, #471011418, CO 291/7-1, CO 291/10-1, CO 291/9-1
• BF
  Bundesministerium für Bildung und Forschung

  Award: FERROPATH (01EJ2205B)
• HE
  HORIZON EUROPE European Research Council