Immunoadjuvant-functionalized metal–organic frameworks: synthesis and applications in tumor immune modulation

Cancer immunotherapy, which leverages the body's immune system to recognize and attack cancer cells, has made significant progress, particularly in the treatment of metastatic tumors. However, challenges such as drug stability and off-target effects still limit its clinical success. To address these issues, metal-organic frameworks (MOFs) have emerged as promising nanocarriers in cancer immunotherapy. MOFs have unique porous structure, excellent drug loading capacity, and tunable surface modification properties. MOFs not only enhance drug delivery efficiency but also allow for precise control of drug release. They reduce off-target effects and significantly improve targeting and therapy efficacy. As research…

• NN
  National Natural Science Foundation of China

  Award: 32101153
• CM
  Capital Medical University
• BI
  Beijing Institute of Technology
• BI
  Beijing Institute of Technology Research Fund Program for Young Scholars