Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy
National Tsing Hua University · National Chung Hsing University · +4 more institutions
Indexed incrossrefpubmed
Abstract
In a sustainable active surface. HFMF-boosted catalytic DON promotes tumors to release tumor-associated antigens, including neoantigens and damage-associated molecular patterns. Then, the porous DON acts as an antigen transporter to deliver autologous tumor-associated antigens to program DCs, resulting in sustained immune stimulation. Catalytic DON combined with the immune checkpoint inhibitor (anti-PD1) in lung metastases suppresses tumors and improves survival over 40 days.
Citation impact
137
total citations
- FWCI
- 22.88
- Percentile
- 100%
- References
- 78
Citations per year
Authors
10- MCMin‐Ren Chiang
National Tsing Hua University
- CHChin-Wei Hsu
National Tsing Hua University
- WPWulin Pan
National Tsing Hua University
- NTNgoc-Tri Tran
National Tsing Hua University
- YLYu-Sheng Lee
National Tsing Hua University
Topics & keywords
Topics
Keywords
- Reprogramming
- Immunotherapy
- Dysfunctional family
- Antigen
- Catalysis
- Chemistry
- Immune system
- Nanotechnology
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Funding
- NHNational Health Research InstitutesAwards: EX112-11111EI, NHRI-EX112-11111EI
- NTNational Tsing Hua UniversityAwards: 111F7MELE1, 111Q2715E1
- USUniversity System of TaiwanAward: VGHUST113-G1-5-2
- TVTaipei Veterans General HospitalAward: VGHUST113-G1-5-2
- NSNational Science and Technology CouncilAwards: NSTC 111-2321-B-A49-009, NSTC 112-2326-B-007-006, 111-2321-B-A49-009, MOST 111-2636-E-007-021, NSTC 112-2314-B-007-005-MY3, MOST-110-2634-F-007-025, NSTC 112-2321-B-007-003, MOST 111-2636-B-007-007, NSTC 112-2321-B-A49-007