MDMA and MDMA-Assisted Therapy
Yale University · Uniformed Services University of the Health Sciences · +5 more institutions
Abstract
MDMA (i.e., 3,4-methylenedixoymethamphetamine), commonly known as "Ecstasy" or "Molly," has been used since the 1970s both in recreational and therapeutic settings. The Food and Drug Administration (FDA) designated MDMA-Assisted Therapy (MDMA-AT) as a Breakthrough Therapy for posttraumatic stress disorder (PTSD) in 2017, and the FDA is requiring an additional phase 3 trial after rejecting the initial New Drug Application in 2024. Unlike other psychedelics, MDMA uniquely induces prosocial subjective effects of heightened trust and self-compassion while maintaining ego functioning as well as cognitive and perceptual lucidity. While recreational use in nonmedical settings may still cause harm, especially due to…
Citation impact
- FWCI
- 76.94
- Percentile
- 100%
- References
- 169
Authors
10- AWAaron WolfgangCorresponding
Yale University, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, University of Minnesota, University of Alabama at Birmingham, Neurobehavioral Systems, Emory University
- GAGregory A. Fonzo
Yale University, Emory University, Neurobehavioral Systems, University of Alabama at Birmingham, Uniformed Services University of the Health Sciences, University of Minnesota, Walter Reed National Military Medical Center
- JCJoshua C. Gray
Neurobehavioral Systems, Emory University, University of Alabama at Birmingham, Walter Reed National Military Medical Center, Yale University, University of Minnesota, Uniformed Services University of the Health Sciences
- JHJohn H. Krystal
University of Alabama at Birmingham, Walter Reed National Military Medical Center, University of Minnesota, Uniformed Services University of the Health Sciences, Yale University, Neurobehavioral Systems, Emory University
- AGAdrienne Grzenda
Walter Reed National Military Medical Center, University of Minnesota, Emory University, Yale University, University of Alabama at Birmingham, Neurobehavioral Systems, Uniformed Services University of the Health Sciences
Topics & keywords
- MDMA
- Ecstasy
- Medicine
- Hallucinogen
- Psychology
- Psychiatry
- Good health and well-being