Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy

Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). In this study, we report the design guidelines towards efficient Type-I semiconducting polymer photosensitizer and modify the best-performing polymer into a hypoxia-tolerant polymeric photosensitizer prodrug (HTPSNiclo) for cancer photo-immunotherapy. HTPSNiclo not only performs Type-I PDT process to partially overcome the limitation of hypoxic tumors in PDT by recycling oxygen but also specifically releases a Signal Transducer and Activator of…

• NR
  National Research Foundation
• NR
  National Research Foundation Singapore

  Award: NRF-NRFI07-2021-0005
• NN
  National Natural Science Foundation of China

  Award: 22322406
• CP
  China Postdoctoral Science Foundation
• MO
  Ministry of Education, India