Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice
University of Kentucky · University of Colorado Anschutz Medical Campus
Abstract
Spinal cord injury (SCI) leads to permanent motor and sensory loss that is exacerbated by intraspinal inflammation and persists months to years after injury. After SCI, monocyte-derived macrophages (MDMs) infiltrate the lesion to aid in myelin-rich debris clearance. During debris clearance, MDMs adopt a proinflammatory phenotype that exacerbates neurodegeneration and hinders recovery. The underlying cause of the lipid-mediated MDM phenotype shift is unclear. Our previous work suggests that cytosolic phospholipase A2 (cPLA2) plays a role in the proinflammatory potentiating effect of myelin on macrophages in vitro. Cytosolic phospholipase A2 (cPLA2) frees arachidonic acid from phospholipids, generating…
Citation impact
- FWCI
- 338.48
- Percentile
- 100%
- References
- 59
Authors
7Topics & keywords
- Proinflammatory cytokine
- Myelin
- Inflammation
- Phospholipase A2
- Microglia
- Cell biology
- Spinal cord injury
- Biology
- Gender equality