In defence of ferroptosis
The University of Melbourne · Florey Institute of Neuroscience and Mental Health
Abstract
Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases, and unlike other cell death programs the physiological initiation of ferroptosis is conceived to occur not by an endogenous executioner, but by the withdrawal of cellular guardians that otherwise constantly oppose ferroptosis induction. Here, we profile key ferroptotic defence strategies including iron regulation, phospholipid modulation and enzymes and metabolite systems: glutathione reductase (GR), Ferroptosis suppressor protein 1 (FSP1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Dihydrofolate reductase (DHFR), retinal reductases…
Citation impact
- FWCI
- 138.64
- Percentile
- 100%
- References
- 522
Authors
5- FAFrancesca AlvesCorresponding
The University of Melbourne, Florey Institute of Neuroscience and Mental Health
- DJDarius J.R. Lane
Florey Institute of Neuroscience and Mental Health
- TPTriet Phu Minh Nguyen
Florey Institute of Neuroscience and Mental Health
- AIAshley I. Bush
The University of Melbourne, Florey Institute of Neuroscience and Mental Health
- SAScott Ayton
The University of Melbourne, Florey Institute of Neuroscience and Mental Health
Topics & keywords
- GPX4
- Nicotinamide adenine dinucleotide phosphate
- Glutaredoxin
- Neurodegeneration
- Lipid peroxidation
- Biology
- Biochemistry
- Programmed cell death
- Good health and well-being