NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo
National University of Singapore · Université Bourgogne Franche-Comté · +1 more institution
Abstract
Strong background interference signals from normal tissues have significantly compromised the sensitive fluorescence imaging of early disease tissues with exogenous probes in vivo, particularly for sensitive fluorescence imaging of early liver disease due to the liver’s significant uptake and accumulation of exogenous nanoprobes, coupled with high tissue autofluorescence and deep tissue depth. As a proof-of-concept study, we herein report a near-infrared-II (NIR-II, 1.0-1.7 μm) light-excited “off-on-off” NIR-II fluorescent probe (NDP). It has near-ideal zero initial probe fluorescence but can turn on its NIR-II fluorescence in liver cancer tissues and then turn off the fluorescence again upon migration from…
Citation impact
- FWCI
- 30.71
- Percentile
- 100%
- References
- 84
Authors
7- YTYufu TangCorresponding
National University of Singapore, Université Bourgogne Franche-Comté
- YLYuanyuan Li
Nanjing University of Posts and Telecommunications
- CHChunxu He
Nanjing University of Posts and Telecommunications
- ZWZhen Wang
Nanjing University of Posts and Telecommunications
- WHWei Huang
Nanjing University of Posts and Telecommunications
Topics & keywords
- Autofluorescence
- Fluorescence
- In vivo
- Fluorescence-lifetime imaging microscopy
- Preclinical imaging
- Liver cancer
- Molecular imaging
- Chemistry