Plasma proteomic signatures of social isolation and loneliness associated with morbidity and mortality
University of Cambridge · Fudan University · +5 more institutions
Abstract
The biology underlying the connection between social relationships and health is largely unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in the UK Biobank, we characterized the proteomic signatures of social isolation and loneliness through proteome-wide association study and protein co-expression network analysis. Proteins linked to these constructs were implicated in inflammation, antiviral responses and complement systems. More than half of these proteins were prospectively linked to cardiovascular disease, type 2 diabetes, stroke and mortality during a 14 year follow-up. Moreover, Mendelian randomization (MR) analysis suggested causal relationships from loneliness to…
Citation impact
- FWCI
- 82.34
- Percentile
- 100%
- References
- 122
Authors
6- CSChun ShenCorresponding
University of Cambridge, Fudan University, Shanghai Institute for Science of Science, Shanghai Center for Brain Science and Brain-Inspired Technology
- RZRuohan Zhang
University of Warwick
- JYJin‐Tai Yu
Fudan University, Huashan Hospital, State Key Laboratory of Medical Neurobiology
- BJBarbara J. Sahakian
University of Cambridge, Fudan University, Shanghai Institute for Science of Science, Shanghai Center for Brain Science and Brain-Inspired Technology
- WCWei Cheng
Fudan University, Huashan Hospital, Shanghai Center for Brain Science and Brain-Inspired Technology, State Key Laboratory of Medical Neurobiology
Topics & keywords
- Loneliness
- Mendelian randomization
- Social isolation
- Disease
- Biobank
- Proteome
- Medicine
- Bioinformatics
- Good health and well-being