A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention

Achilles tendon is a motor organ that is prone to tissue adhesion during its repair process after rupture. Therefore, developing motion-responsive and anti-adhesive biomaterials is an important need for the repair of Achilles tendon rupture. Here, we report an injectable lubricative hydrogel (ILH) based on hydration lubrication mechanism, which is also motion-responsive based on sol-gel reversible transmission. The lubrication performance is achieved by zwitterionic polymers as we previously proved, and the sol-gel reversible transmission is enabled by dynamic disulfide bonds. Firstly, ILH was proved to be successfully prepared and lubricated as well as sol-gel reversible via FTIR characterization, rheological…

• NS
  Natural Science Foundation of Hebei Province

  Award: H2022201064
• NS
  Natural Science Foundation of Beijing Municipality

  Award: 2244086
• SK
  State Key Laboratory of Tribology

  Award: SKLTKF22B01