An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and migration. Deregulated NF-kB signaling resulted in unregulated cell proliferation, viability, movement, and invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals that inhibit NF-κB signaling have the potential to be employed in cancer therapeutics. Flavonoids are a group of polyphenolic natural compounds present in various plants and their fruits, vegetables, and leaves. These compounds have…

• NR
  National Research Foundation

  Awards: 2020R1I1A2066868, 2020R1A5A2019413
• NR
  National Research Foundation of Korea

  Awards: 2020R1I1A2066868, NRF-2020R1I1A2066868, RS-2024-00350362, 2020R1A5A2019413
• MO
  Ministry of Science and ICT, South Korea

  Award: 2020R1A5A2019413