Tumor microenvironment-responsive engineered hybrid nanomedicine for photodynamic-immunotherapy via multi-pronged amplification of reactive oxygen species
East China University of Science and Technology · Tongji University · +5 more institutions
Abstract
Reactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments. To tackle this issue, we develop a pH/redox dual-responsive nanomedicine based on the remodeling of cancer-associated fibroblasts (CAFs) for multi-pronged amplification of ROS (ZnPP@FQOS). It is demonstrated that ROS generated by ZnPP@FQOS is endogenously/exogenously multiply amplified…
Citation impact
- FWCI
- 40.79
- Percentile
- 100%
- References
- 50
Authors
11- JZJinglin ZouCorresponding
East China University of Science and Technology
- CJCong Jiang
Tongji University, Shanghai Pulmonary Hospital
- QHQiangsheng Hu
Tongji University, Shanghai Pulmonary Hospital
- XJXinlin Jia
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- SWShuqi Wang
East China University of Science and Technology
Topics & keywords
- Tumor microenvironment
- Cancer research
- Tumor hypoxia
- Photodynamic therapy
- Reactive oxygen species
- Cancer immunotherapy
- Nanomedicine
- Oxidative stress