Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions

Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic and metabolic dysfunction-associated alcoholic liver disease (MetALD), and viral hepatitis, can lead to liver fibrosis, cirrhosis, and cancer. Hepatic stellate cell (HSC) activation plays a central role in the development of myofibroblasts and fibrogenesis in chronic liver diseases. However, HSC activation is influenced by the complex microenvironments within the liver, which are largely shaped by the interactions between HSCs and various other cell types. Changes in HSC phenotypes and metabolic mechanisms involve glucose, lipid, and cholesterol metabolism, oxidative stress, activation of the unfolded…

• NS
  National Science Foundation
• PU
  Peking University First Hospital

  Award: 2023IR06
• NN
  National Natural Science Foundation of China

  Awards: 82274024, 82073935
• PU
  Peking University