Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK

Papier, Keren; Bradbury, Kathryn E.; Balkwill, Angela; Barnes, Isobel; Smith-Byrne, Karl; Gunter, Marc J.; Berndt, Sonja; Marchand, Loı̈c Le; Wu, Anna H.; Peters, Ulrike; Beral, Valerie; Key, Timothy J.; Reeves, Gillian

doi:10.1038/s41467-024-55219-5

articleNature CommunicationsJan 8, 2025GOLD OA

Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK

KPKeren Papier KEKathryn E. Bradbury ABAngela Balkwill IBIsobel Barnes KSKarl Smith-Byrne

University of Oxford · University of Auckland · +10 more institutions

PubMed

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Abstract

Uncertainty remains regarding the role of diet in colorectal cancer development. We examined associations of 97 dietary factors with colorectal cancer risk in 542,778 Million Women Study participants (12,251 incident cases over 16.6 years), and conducted a targeted genetic analysis in the ColoRectal Transdisciplinary Study, Colon Cancer Family Registry, and Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Alcohol (relative risk per 20 g/day=1.15, 95% confidence interval 1.09-1.20) and calcium (per 300 mg/day=0.83, 0.77-0.89) intakes had the strongest associations, followed by six dairy-related factors associated with calcium. We showed a positive association with red and processed meat intake…

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Topics & keywords

Topics

Keywords

Colorectal cancer
Medicine
Relative risk
Vitamin D and neurology
Red meat
Epidemiology
Confidence interval
Cancer

UN Sustainable Development Goals

Good health and well-being

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