AI-Based Prediction of Protein Corona Composition on DNA Nanostructures

DNA nanotechnology has emerged as a powerful approach to engineering biophysical tools, therapeutics, and diagnostics because it enables the construction of designer nanoscale structures with high programmability. Based on DNA base pairing rules, nanostructure size, shape, surface functionality, and structural reconfiguration can be programmed with a degree of spatial, temporal, and energetic precision that is difficult to achieve with other methods. However, the properties and structure of DNA constructs are greatly altered in vivo due to spontaneous protein adsorption from biofluids. These adsorbed proteins, referred to as the protein corona, remain challenging to control or predict, and subsequently, their…

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  Helen Wills Neuroscience Institute, University of California Berkeley
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  University of California Berkeley
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  University of California, San Diego
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  Division of Chemical, Bioengineering, Environmental, and Transport Systems

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  Division of Civil, Mechanical and Manufacturing Innovation

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