Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS‐STING Activation for Bidirectional Synergistic Hydrogen‐Immunotherapy

Abstract The cGAS‐STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cGAS‐STING pathway. Herein, Mn galvanic cells (MnG) are prepared via liquid‐phase exfoliation and in situ galvanic replacement to modulate tumor metabolism, thereby enhancing cGAS‐STING activation for bidirectional synergistic H 2 ‐immunotherapy. The obtained MnG can be etched by water, enabling efficient and sustained generation of H 2 gas and Mn 2+ . MnG not only activated and amplified the cGAS‐STING pathway through the sustained release of Mn 2+ but also regulated tumor glucose metabolism to inhibit the expression of three prime repair…

• NN
  National Natural Science Foundation of China

  Awards: 52072253, 52403386, U20A20254, 52472288
• HE
  Higher Education Discipline Innovation Project