Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy
Central South University · Xiangya Hospital Central South University
Abstract
Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Metabolic dysregulation creates an immunosuppressive TME, impairing the antitumor immune response. In this review, we discuss how metabolic regulators affect the tumor cell and the crosstalk of TME. We also summarize recent clinical trials involving metabolic regulators and the challenges of metabolism-based tumor therapies in clinical translation. In a word, our review distills key regulatory factors and their…
Citation impact
- FWCI
- 56.37
- Percentile
- 100%
- References
- 225
Authors
6- KHKun HuangCorresponding
Central South University, Xiangya Hospital Central South University
- YHYing Han
Central South University, Xiangya Hospital Central South University
- YCYihong Chen
Central South University, Xiangya Hospital Central South University
- HSHong Shen
Central South University, Xiangya Hospital Central South University
- SZShan Zeng
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Tumor microenvironment
- Reprogramming
- Biology
- Crosstalk
- Immune system
- Cancer research
- Tumor progression
- Stromal cell
- Good health and well-being