Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via  Akkermansia muciniphila

Pan, Miaomiao; Qian, Chenhao; Huo, Shaoye; Wu, Yuchen; Zhao, Xinyi; Ying, Yueming; Wang, Boyu; Yang, Hao; Yeerken, Anaguli; Wang, Tongyao; Fu, Mengwei; Wang, Lihong; Wei, Yuhuan; Zhao, Yunhua; Shao, Chunhai; Wang, Huijing; Zhao, Chao

doi:10.1080/19490976.2024.2447834

articleGut MicrobesJan 9, 2025GOLD OA

Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila

MPMiaomiao Pan CQChenhao Qian SHShaoye Huo YWYuchen Wu XZXinyi Zhao

Fudan University · Huashan Hospital · +5 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Collaboratively restore the imbalance in tryptophan metabolism, leading to increased 5-HT activity and alleviating anxiety phenotypes. This study highlights the intricate interplay between gut metabolites and anxiety regulation, offering potential avenues for microbiota-targeted therapeutic strategies for anxiety.

Citation impact

total citations

FWCI: 18.98
Percentile: 100%
References: 55

Citations per year

Authors

MP
Miaomiao Pan
Fudan University, Huashan Hospital
CQ
Chenhao Qian
Fudan University, Huashan Hospital
SH
Shaoye Huo
Fudan University
YW
Yuchen Wu
Shanghai University of Medicine and Health Sciences
XZ
Xinyi Zhao
Shanghai American School, Vanke (China)

Topics & keywords

Topics

Tryptophan and brain disorders100%
Gut microbiota and health100%
Stress Responses and Cortisol98%

Keywords

Akkermansia muciniphila
Biology
Kynurenine
Gut flora
Serotonin
Tryptamine
Tryptophan
Akkermansia

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

SM
Shanghai Municipal Health Commission
Award: 2022XD051
RA
Research and Development