Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail

Prajapati, Santosh Kumar; Wang, Shaohua; Mishra, Sidharth P.; Jain, Shalini; Yadav, Hariom

doi:10.1038/s41598-024-84780-8

articleScientific ReportsJan 10, 2025GOLD OA

Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail

SKSantosh Kumar Prajapati SWShaohua Wang SPSidharth P. Mishra SJShalini Jain HYHariom Yadav

University of South Florida

PubMed

Indexed incrossrefdoajpubmed

Abstract

Microbiome abnormalities (dysbiosis) significantly contribute to the progression of Alzheimer’s disease (AD). However, the therapeutic efficacy of microbiome modulators in protecting against these ailments remains poorly studied. Herein, we tested a cocktail of unique probiotics, including 5 Lactobacillus and 5 Enterococcus strains isolated from infant gut with proven microbiome modulating capabilities. We aimed to determine the probiotics cocktail’s efficacy in ameliorating AD pathology in a humanized AD mouse model of APP/PS1 strains. Remarkably, feeding mice with 1 × 1011 CFU per day in drinking water for 16 weeks significantly reduced cognitive decline (measured by the Morris Water Maze test) and AD…

Citation impact

48

total citations

FWCI: 29.58
Percentile: 100%
References: 92

Citations per year

Authors

5

Topics & keywords

Topics

Keywords

Neuroinflammation
Microbiome
Inflammation
Dysbiosis
Blood–brain barrier
Cognitive decline
Intestinal permeability
Disease

UN Sustainable Development Goals

Clean water and sanitation

No related works found for this paper.