RNA dysregulation in neurodegenerative diseases

Dysregulation of RNA processing has in recent years emerged as a significant contributor to neurodegeneration. The diverse mechanisms and molecular functions underlying RNA processing underscore the essential role of RNA regulation in maintaining neuronal health and function. RNA molecules are bound by RNA-binding proteins (RBPs), and interactions between RNAs and RBPs are commonly affected in neurodegeneration. In this review, we highlight recent progress in understanding dysregulated RNA-processing pathways and the causes of RBP dysfunction across various neurodegenerative diseases. We discuss both established and emerging mechanisms of RNA-mediated neuropathogenesis in this rapidly evolving field.…

• UD
  U.S. Department of Defense
• TA
  Target ALS
• NI
  National Institutes of Health

  Awards: RF1NS113820, R01AG078948, RF1NS127925
• NI
  National Institute on Aging

  Award: R01AG078948
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: RF1NS127925, RF1NS113820
• CD
  Congressionally Directed Medical Research Programs

  Award: HT94252410142