Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy

Hypoxic tumors present a significant challenge in cancer therapy due to their ability to adaptation in low-oxygen environments, which supports tumor survival and resistance to treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is a crucial mechanism that helps sustain cellular homeostasis in hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, that co-delivers hydroxychloroquine and a mitochondria-targeting photosensitizer, designed to induce cascaded oxidative stress by regulating mitophagy for the treatment of hypoxic tumors. These nanoparticles are hypoxia-responsive and release loaded guest molecules in hypoxic tumor…

• NN
  National Natural Science Foundation of China

  Awards: U20A20259, 32071342, 32101065, 32471390
• NS
  Natural Science Foundation of Guangdong Province

  Award: 2023A1515012015