Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell cycle progression, having been first identified as the kinases able to drive cell division. In reality, the human genome contains 20 different CDKs, which can be divided in at least three different sub-family with different functions, mechanisms of regulation, expression patterns and subcellular localization. Most of these kinases play fundamental roles the normal physiology of eucaryotic cells; therefore, their deregulation is associated with the onset and/or progression of multiple human disease including but not limited to neoplastic and neurodegenerative conditions. Here, we describe the functions of CDKs, categorized into the…

• MD
  Ministero della Salute

  Awards: RF-2021-12371961, 2018-, GR-2021-12373937, GR- 2021-12373937, CO-2018-1236705, PNRR-MAD-2022-12375663
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca

  Award: ARS01_00568
• AI
  Associazione Italiana per la Ricerca sul Cancro

  Awards: IG 26253, 20061, IG 20061, MFAG 28993