Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment
Tianjin Medical University Cancer Institute and Hospital · Tianjin Medical University · +2 more institutions
Abstract
• Baicalin strengthened the antitumor immune activity of activated PBMCs to OSCC in co-culture system. • Baicalin repressed the lactate accumulation, acidification and m 6 A modification of OSCC cells. • Baicalin targeted LDHA via m 6 A-IGF2BP3-dependent manner to reduce lactate accumulation. • Baicalin attenuates lactate-induced acidification to reduce OSCC immune escape in tumor microenvironment. The acidic microenvironment caused by excessive lactate accumulation could inhibit immune lymphocytes antitumor activity and promote the immune escape of tumor cells. Baicalin is an active flavonoid isolated from Scutellaria baicalensis Georgi, a traditional Chinese medicinal herb with antioxidant and…
Citation impact
- FWCI
- 53.56
- Percentile
- 100%
- References
- 26
Authors
7- YCYameng Cui
Tianjin Medical University Cancer Institute and Hospital
- JLJingwen Liu
Tianjin Medical University, Tianjin Medical University General Hospital
- XWXi Wang
Second Hospital of Tianjin Medical University, Tianjin Medical University
- YWYu‐Lin Wu
Tianjin Medical University Cancer Institute and Hospital
- YCYunhan Chang
Tianjin Medical University General Hospital, Tianjin Medical University
Topics & keywords
- Basal cell
- Tumor microenvironment
- Immune system
- Cancer research
- Baicalin
- Chemistry
- Medicine
- Internal medicine
- Zero hunger