Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition
University of Palermo · National University of Singapore · +33 more institutions
Abstract
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and invasiveness and promote metastasis and cancer progression. By targeting various components of the TME, novel…
Citation impact
- FWCI
- 90.55
- Percentile
- 100%
- References
- 1,203
Authors
39Topics & keywords
- Tumor microenvironment
- Epithelial–mesenchymal transition
- Metastasis
- Cancer research
- Cancer
- Cancer cell
- Tumor progression
- Mesenchymal stem cell
- Good health and well-being
Funding
- UDU.S. Department of DefenseAwards: R01CA237027, R01CA240290, P30CA016056, PC220137
- PCProstate Cancer Foundation
- RPRoswell Park Cancer InstituteAwards: R01CA237027, R01CA240290, P30CA016056
- MSMemorial Sloan-Kettering Cancer Center
- NUNational University of SingaporeAward: MOE-T2EP30120-0016
- MOMinistry of Education - SingaporeAward: MOE-T2EP30120-0016
- MOMinistry of Education, India
- NUNational University Health SystemAward: NUHSRO/2023/039/RO5+6/Seed-Mar/04
- NINational Institutes of HealthAwards: R01CA240290, R01CA237027, P30CA016056
- NCNational Cancer InstituteAwards: P30CA016056, R01CA237027, R01CA240290