Digestive cancers: mechanisms, therapeutics and management
Heidelberg University · University Hospital Heidelberg · +5 more institutions
Abstract
Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. This knowledge is continuously translated into novel treatment concepts and targets, which are dynamically reshaping the therapeutic landscape of these tumors. In this review, we provide a…
Citation impact
- FWCI
- 36.91
- Percentile
- 100%
- References
- 581
Authors
10- TZTianzuo ZhanCorresponding
Heidelberg University, University Hospital Heidelberg, European Molecular Biology Laboratory, University Medical Centre Mannheim
- JBJohannes Betge
German Cancer Research Center, Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim
- NSNadine Schulte
Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim
- LDLena Dreikhausen
Heidelberg University, University Hospital Heidelberg, European Molecular Biology Laboratory, University Medical Centre Mannheim
- MHMichael Hirth
Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim
Topics & keywords
- Cancer
- Immunotherapy
- Pancreatic cancer
- Medicine
- Immune system
- Etiology
- Cancer immunotherapy
- Bioinformatics
- Good health and well-being