Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance
Qingdao University · Mawlana Bhashani Science and Technology University · +1 more institution
Abstract
Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by its rapid degradation, limited bioavailability, and poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area and tunable pore size, is designed and used as a cur delivery carrier to overcome these limitations. The synthesis of cur-loaded ZIF-8 involves a solvothermal method, followed by encapsulation of cur within the porous structure of ZIF-8. The amount of cur was varied to synthesize a series of panel cur-loaded ZIF-8. 0.5 mg/mL cur@ZIF-8 that showed higher drug loading efficiency (85.91 ± 1.26%)…
Citation impact
- FWCI
- 25.97
- Percentile
- 100%
- References
- 71
Authors
8Topics & keywords
- Curcumin
- Nanomaterials
- Drug
- Nanotechnology
- Materials science
- Pharmacology
- Medicine