Clinical criteria for limbic‐predominant age‐related TDP‐43 encephalopathy

Limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is highly prevalent in late life and a common co-pathology with Alzheimer's disease neuropathologic change (ADNC). LATE-NC is a slowly progressive, amnestic clinical syndrome. Alternatively, when present with ADNC, LATE-NC is associated with a more rapid course. With the emergence of anti-amyloid therapeutics, discrimination of LATE-NC from ADNC is critical and will lead to greater clinical recognition of amnestic patients without ADNC. Furthermore, co-pathology with LATE-NC may influence outcomes of these therapeutics. Thus there is a need to identify patients during life with likely LATE-NC. We propose criteria for clinical…

• NI
  National Institutes of Health

  Awards: R01AG034374, R01 AG064233, K23AG062750, P01 AG066597, P30AG072979, P30 AG066509, AG066597, R01AG080667, AG066509