GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases

Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers1. T cells participate in a wide range of inflammatory diseases such as psoriasis2, Crohn’s disease3, oesophagitis4 and multiple sclerosis5,6, and clonally expanded antigen-specific T cells may contribute to disease chronicity and recurrence, in part by forming persistent pathogenic memory. Chronic rhinosinusitis and asthma are inflammatory airway diseases that often present as comorbidities7. Chronic rhinosinusitis affects more than 10% of the general population8. Among these patients, 20–25% would develop nasal polyps, which often require repeated surgical resections owing to a high…

• NN
  National Natural Science Foundation of China

  Awards: IRT13082, T2225005, 81970851, 32130037, 21927802, 82271140
• TU
  Tsinghua University
• PU
  Peking University
• NS
  National Science and Technology Major Project
• NH
  National Health Commission of the People's Republic of China

  Award: 2023ZD0519900
• CF
  China-Japan Friendship Hospital