Exploring TNFR1: from discovery to targeted therapy development
Shanghai University · Shanghai University of Medicine and Health Sciences · +1 more institution
Abstract
This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1 (TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which are associated with pro-inflammatory responses and cell death. The intricate regulatory mechanisms of TNFR1 signaling and its involvement in various diseases, including inflammatory disorders, infectious diseases, cancer, and metabolic syndromes, have attracted increasing scholarly attention. Given the potential risks associated with targeting tumor necrosis factor-alpha (TNF-α),…
Citation impact
- FWCI
- 28.88
- Percentile
- 100%
- References
- 216
Authors
7Topics & keywords
- Medicine
- Bioinformatics
- Computational biology
- Biology