Photoinduced Late‐Stage Radical Decarboxylative and Deoxygenative Coupling of Complex Carboxylic Acids and Their Derivatives

The simple and efficient conversion of carboxylic acids into structurally diverse organic molecules is highly desirable in chemical synthesis. This review covers recent developments in photocatalytic methodology for late-stage transformations of complex carboxylic acids and their derivatives enabled by radical decarboxylation and deoxygenation, highlighting some representative and significant contributions in this field. These advancements are categorized based on the reactivity patterns exhibited by the carboxylic acids. Several activation modes to generate alkyl or aryl radical intermediates during decarboxylation of carboxylic acids are presented, namely, single-electron transfer (SET) oxidation,…

• NN
  National Natural Science Foundation of China

  Award: 22001117, 22301132 and 22471121
• KT
  Key Technologies Research and Development Program

  Award: 2022YFA1503200 and 2021YFC2101901