NADPH oxidases: redox regulation of cell homeostasis and disease
University of Pittsburgh · University of Zurich · +5 more institutions
Abstract
The redox signaling network in mammals has garnered enormous interest and taken on major biological significance in recent years as the scope of NADPH oxidases (NOXs) as regulators of physiological signaling and cellular degeneration has grown exponentially. All NOX isoforms have in common the capacity to generate reactive oxygen species (ROS) superoxide anion (O 2 •− ) and/or hydrogen peroxide (H 2 O 2 ). A baseline, normal level of ROS formation supports a wide range of processes under physiological conditions. A disruption in redox balance caused by either the suppression or “super” induction of NOX off balance with antioxidant systems is associated with myriad diseases and cell/tissue damage. Over the past…
Citation impact
- FWCI
- 37.77
- Percentile
- 100%
- References
- 1,335
Authors
4- DKDamir Kračun
University of Pittsburgh, University of Zurich, ETH Zurich, University Hospital of Zurich, Universitätsklinik Balgrist
- LRLucia Rossetti Lopes
ETH Zurich, Institute for Biomedical Engineering, Institute of Biomedical Science
- ECEugenia Cifuentes-Pagano
University of Pittsburgh
- PJPatrick J. PaganoCorresponding
University of Pittsburgh
Topics & keywords
- Homeostasis
- Redox
- Cell biology
- Cell
- Chemistry
- Oxidation reduction
- Biochemistry
- Biology