How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health
John Radcliffe Hospital · University of Oxford · +3 more institutions
Abstract
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm. Metabolic changes, such as high blood glucose levels and increased body weight, are commonly observed in the offspring of fathers subjected to chronic stress, in addition to an enhanced risk of depressive-like behaviour and…
Citation impact
- FWCI
- 25.88
- Percentile
- 100%
- References
- 197
Authors
4- AAAyazhan Akhatova
John Radcliffe Hospital, University of Oxford, Nazarbayev University
- CJCéline Jones
John Radcliffe Hospital, University of Oxford
- KCKevin Coward
John Radcliffe Hospital, University of Oxford
- MYMarc YesteCorresponding
Institució Catalana de Recerca i Estudis Avançats, Universitat de Girona
Topics & keywords
- Epigenome
- Offspring
- Sperm
- Reproductive medicine
- Biology
- Embryo
- Andrology
- Human genetics