articleNature CommunicationsJan 16, 2025GOLD OA

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions

RMRicardo Martins-FerreiraJCJosep Calafell-SeguraBLBárbara LealJRJavier Rodríguez‐UbrevaEMElena Martínez‐Sáez

Universidade do Porto · Josep Carreras Leukaemia Research Institute · +6 more institutions

PubMed
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Abstract

Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression. We constructed an atlas of human brain immune cells by integrating nineteen single-nucleus RNA-seq and single-cell RNA-seq datasets from multiple neurodegenerative conditions, comprising 241 samples from patients with Alzheimer’s disease, autism spectrum disorder, epilepsy, multiple sclerosis, Lewy body diseases, COVID-19, and healthy controls. The integrated Human Microglia Atlas (HuMicA) included 90,716 nuclei/cells and revealed nine populations distributed across all conditions. We identified four subtypes of disease-associated microglia and disease-inflammatory macrophages,…

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Topics & keywords

Topics
Keywords
  • Microglia
  • Neuroscience
  • Atlas (anatomy)
  • Disease
  • Biology
  • Medicine
  • Immunology
  • Pathology
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