Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease

Atherosclerosis is accompanied by inflammation that underlies cardiovascular disease (CVD) and its vascular manifestations, including acute stroke, myocardial infarction, and peripheral artery disease, the leading causes of morbidity/mortality worldwide. The monolayer of endothelial cells formed on the luminal surface of arteries and veins regulates vascular tone and permeability, which supports vascular homeostasis. Endothelial dysfunction, the first step in the development of atherosclerosis, is caused by mechanical and biochemical factors that disrupt vascular homeostasis and induce inflammation. Together with increased plasma levels of low-density lipoprotein (LDL), diabetes, hypertension, cigarette…

• AH
  American Heart Association

  Awards: 2018/29/B/NZ4/00771, 17GRNT32910002, 2019/33/B/NZ4/01760
• NC
  Narodowe Centrum Nauki

  Awards: 17GRNT32910002, 2019/33/B/NZ4/01760, 2018/29/B/NZ4/00771, 2021/43/B/NZ4/00339