Framework Nucleic Acid-Based and Neutrophil-Based Nanoplatform Loading Baicalin with Targeted Drug Delivery for Anti-Inflammation Treatment

Targeted drug delivery is a promising strategy for treating inflammatory diseases, with recent research focusing on the combination of neutrophils and nanomaterials. In this study, a targeted nanodrug delivery platform (Ac-PGP-tFNA, APT) was developed using tetrahedral framework nucleic acid (tFNA) along with a neutrophil hitchhiking mechanism to achieve precise delivery and anti-inflammatory effects. The tFNA structure, known for its excellent drug-loading capacity and cellular uptake efficiency, was used to carry a therapeutic agent─baicalin. The results demonstrate that the development of this drug delivery platform not only considerably enhances the bioavailability and effective concentration of the drug…

• NN
  National Natural Science Foundation of China

  Awards: 82370929, 82301146
• CP
  China Postdoctoral Science Foundation

  Awards: BX20220220, 2022M722251
• DO
  Department of Science and Technology of Sichuan Province

  Awards: 2022NSFSC0002, 2023NSFSC1706
• SP
  Sichuan Province Youth Science and Technology Innovation Team

  Award: 2022JDTD0021
• WC
  West China School of Stomatology, Sichuan University

  Awards: RCDWJS2023-14, RCDWJS2024-1, RD03202302