Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds
Birla Institute of Technology and Science, Pilani · Indian Institute of Science Bangalore
Abstract
In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry. Consequently, the reactions operating in a single-pot and yielding novel rings or new substitution patterns under mild conditions are highlighted. Moreover, MCRs that do not require special reagents or catalysts and yield diverse products from commercially available building blocks are reviewed. The synthetic schemes, substrate scope, and other key aspects such as regio- and stereoselectivity are…
Citation impact
- FWCI
- 41.60
- Percentile
- 100%
- References
- 155
Authors
4Topics & keywords
- Chemical space
- Chemistry
- Combinatorial chemistry
- Nanotechnology
- Materials science
- Drug discovery
- Biochemistry