Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies
University of Eastern Finland · Indian Council of Medical Research · +7 more institutions
Abstract
Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of a wide range of brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) cause neuroinflammation, alter brain function, and accelerate disease development. Despite progress in understanding these pathways, effective medicines targeting brain inflammation are still limited. Traditional anti-inflammatory and immunomodulatory drugs are effective in peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to the central nervous…
Citation impact
- FWCI
- 37.90
- Percentile
- 100%
- References
- 198
Authors
9- RMRahul Mallick
University of Eastern Finland
- SBSanjay Basak
Indian Council of Medical Research, National Institute of Nutrition
- PCPremanjali Chowdhury
University of Eastern Finland
- PBPrasenjit Bhowmik
Uppsala University, Green University of Bangladesh
- RKRanjit Kumar Das
The University of Texas Rio Grande Valley
Topics & keywords
- Inflammation
- Medicine
- Cytokine
- Bioinformatics
- Immunology
- Biology